Releasing COVID-19 Cases from Isolation and Quarantine



Must be isolated for a minimum of 10 days after symptom onset (or specimen collection date if asymptomatic) and can be released when the following criteria are met:

  • Case is afebrile (without fever-reducing medication) for at least 24 hours and with improvement of COVID-19 symptoms.


  • Case Has 2 Negative COVID-19 PCR tests in a row, with specimens collected and testing done at least 24 hours apart

A test-based strategy is no longer recommended in the majority of cases. Consult with infectious disease physician.

*A limited number of persons with severe illness or who are severely immunosuppressed may produce replication-competent virus beyond 10 days; this may warrant extending duration of isolation and precautions for up to 20 days after symptom onset or first positive test (if no symptoms). Consult with the infectious disease physician.

Close Contacts

Must be quarantined for 14 days after the last/most recent contact with the case when the case was infectious.

If a close contact develops symptoms, they should follow isolation rules for cases.

Contact Scenario Quarantine Period
Has close contact with someone who has COVID-19 and will not have further close contact 14 days from the date of last close contact
Has close contact with someone who has COVID-19 and lives with the case but can avoid further close contact 14 days from when the person with COVID-19 began home isolation away from other members of the household
Is under quarantine and had additional close contact with someone else who has COVID-19 Restart quarantine from the last day close contact occurred with anyone who has COVID19. Any time a new household member gets sick with COVID-19 and close contact occurs, quarantine will need to be restarted
Lives with someone who has COVID19 and cannot avoid continued close contact (e.g., shared kitchen/bathroom) Quarantine for 14 days after the person who has COVID-19 meets the criteria to end home isolation (see Cases information).
Was previously diagnosed with COVID-19 but did not undergo SARSCoV-2 testing and is now a close contact to a confirmed COVID-19 case Quarantine for 14 days from the date of last close contact to the COVID-19 case. Antibody testing results are not considered when determining quarantine status.

For COVID-19, a close contact is defined as being within 6 feet of an infected person for a cumulative total of 15 minutes or more over a 24-hour period starting from 2 days before illness onset (or, for asymptomatic patients, 2 days prior to test specimen collection) until the time the case is isolated. For additional information, see

Guidance for Healthcare Worker Contacts:

Guidance for Critical Workers in Essential Infrastructure: 

Interim guidance, revision 10. 23. 2020. Subject to change.




Debe aislarse durante un mínimo de 10 días después de la aparición de los síntomas y se puede liberar después de la afebril y sentirse bien (sin medicación para reducir la fiebre) durante al menos 24 horas. durante al menos 24 horas
Tiene 2 pruebas COVID-19 negativas seguidas, con pruebas realizadas con al menos 24 horas de diferencia

Cerca Contactos1

Debe estar en cuarentena durante 14 días después del último/más reciente contacto con el caso cuando el caso fue infeccioso2

Si un contacto cercano presenta síntomas, debe seguir las reglas de aislamiento para los casos anteriores.

Contactos del Hogar:

Contactos domésticos con viviendas separadas entre el caso y los contactos: cuarentena durante 14 días después de la última exposición al caso.

Residentes de LTC o Contactos domésticos que comparten una habitación/sala de estar (es decir, tienen contacto continuo o exposición al caso): cuarentena durante el contacto y durante 14 días después de que el caso se libere del aislamiento.

1 Los contactos cercanos incluyen contactos domésticos, contactos íntimos o contactos dentro de 6 pies a 10 minutos o más
Orientación Para los Contactos de los Trabajadores Sanitarios:
Orientación Para Trabajadores Críticos en Infraestructura Esencial:
2 Consulte la guía de caso anterior para determinar cuándo el caso ya no se considera infeccioso. Tenga en cuenta que el período de tiempo de exposición al contacto incluiría las 48 horas anteriores a la aparición de los síntomas del caso o la fecha de recolección positiva de la prueba, si corresponde.

Orientación provisional, revisión 5.4.2020. Sujeto a cambios